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- Title
Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice.
- Abstract
The article offers information on a study conducted on the protective role of an intestinal stem cell growth factor, R-spondin1, against radiation-induced gastrointestinal syndrome (RIGS) in mice. It states that the late side effects of severe acute intestinal radiation injury includes intestinal inflammation, collagen deposition and fibrosis. It mentions that RIGS results in part from radiation-induced DNA damage, cell death and cell cycle arrest in intestinal crypt cells. It presents that ionizing radiation induces apoptosis of intestinal crypt epithelial cells.
- Publication
PLoS ONE, 2009, Vol 4, Issue 11, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0008014