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Title
Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.
Authors
Holmes, Michael V; Shah, Tina; Vickery, Christine; Smeeth, Liam; Hingorani, Aroon D; Casas, Juan P
Abstract
Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics).