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- Title
G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies.
- Authors
Nakamura, Kenta; Salomonis, Nathan; Tomoda, Kiichiro; Yamanaka, Shinya; Conklin, Bruce R
- Abstract
Reprogramming adult human somatic cells to create human induced pluripotent stem (hiPS) cell colonies involves a dramatic morphological and organizational transition. These colonies are morphologically indistinguishable from those of pluripotent human embryonic stem (hES) cells. G protein-coupled receptors (GPCRs) are required in diverse developmental processes, but their role in pluripotent colony morphology and organization is unknown. We tested the hypothesis that G(i)-coupled GPCR signaling contributes to the characteristic morphology and organization of human pluripotent colonies.
- Publication
PloS one, 2009, Vol 4, Issue 11, pe7780
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0007780