We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mbd3, a Component of NuRD/Mi-2 Complex, Helps Maintain Pluripotency of Mouse Embryonic Stem Cells by Repressing Trophectoderm Differentiation.
- Abstract
The article focuses on a study which examines the functions of Methyl-CpG-binding domain protein 3 (Mbd3) in mouse Embryonic stem cells (ES cells). It states that ES cells can be differentiated into cells derived from all three germ layers and extraembryonic tissues. As mentioned, two wild type ES cells were compared in the study known as Mbd3 knockdown cells. It mentions that Mbd3 plays an important role in repression of respective genes in undifferentiated ES cells. It also mentions that these changes are not sufficient for definitive differentiation to trophectoderm (TE) in chimeric embryos.
- Publication
PLoS ONE, 2009, Vol 4, Issue 11, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0007684