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- Title
A statistical model of protein sequence similarity and function similarity reveals overly-specific function predictions.
- Authors
Louie, Brenton; Higdon, Roger; Kolker, Eugene
- Abstract
Predicting protein function from primary sequence is an important open problem in modern biology. Not only are there many thousands of proteins of unknown function, current approaches for predicting function must be improved upon. One problem in particular is overly-specific function predictions which we address here with a new statistical model of the relationship between protein sequence similarity and protein function similarity.
- Publication
PloS one, 2009, Vol 4, Issue 10, pe7546
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0007546