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- Title
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
- Authors
Noll, Christophe; Planque, Chris; Ripoll, Clémentine; Guedj, Fayçal; Diez, Anna; Ducros, Véronique; Belin, Nicole; Duchon, Arnaud; Paul, Jean-Louis; Badel, Anne; de Freminville, Bénédicte; Grattau, Yann; Bléhaut, Henri; Herault, Yann; Janel, Nathalie; Delabar, Jean-Maurice
- Abstract
Hyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosis. We previously found a deleterious effect of hyperhomocysteinemia on expression of DYRK1A, a Down-syndrome-associated kinase. As increased expression of DYRK1A and low plasma homocysteine level have been associated with Down syndrome, we aimed to analyze the effect of its over-expression on homocysteine metabolism in mice.
- Publication
PloS one, 2009, Vol 4, Issue 10, pe7540
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0007540