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- Title
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.
- Authors
Dubreuil, Patrice; Letard, Sébastien; Ciufolini, Marco; Gros, Laurent; Humbert, Martine; Castéran, Nathalie; Borge, Laurence; Hajem, Bérengère; Lermet, Anne; Sippl, Wolfgang; Voisset, Edwige; Arock, Michel; Auclair, Christian; Leventhal, Phillip S; Mansfield, Colin D; Moussy, Alain; Hermine, Olivier
- Abstract
The stem cell factor receptor, KIT, is a target for the treatment of cancer, mastocytosis, and inflammatory diseases. Here, we characterise the in vitro and in vivo profiles of masitinib (AB1010), a novel phenylaminothiazole-type tyrosine kinase inhibitor that targets KIT.
- Publication
PloS one, 2009, Vol 4, Issue 9, pe7258
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0007258