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- Title
Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines.
- Authors
Debeb, Bisrat G; Galat, Vasiliy; Epple-Farmer, Jessica; Iannaccone, Steve; Woodward, Wendy A; Bader, Michael; Iannaccone, Philip; Binas, Bert
- Abstract
The extraembryonic endoderm (ExEn) defines the yolk sac, a set of membranes that provide essential support for mammalian embryos. Recent findings suggest that the committed ExEn precursor is present already in the embryonic Inner Cell Mass (ICM) as a group of cells that intermingles with the closely related epiblast precursor. All ICM cells contain Oct4, a key transcription factor that is first expressed at the morula stage. In vitro, the epiblast precursor is most closely represented by the well-characterized embryonic stem (ES) cell lines that maintain the expression of Oct4, but analogous ExEn precursor cell lines are not known and it is unclear if they would express Oct4.
- Publication
PloS one, 2009, Vol 4, Issue 9, pe7216
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0007216