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- Title
Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells.
- Authors
Vercoulen, Yvonne; Wehrens, Ellen J; van Teijlingen, Nienke H; de Jager, Wilco; Beekman, Jeffrey M; Prakken, Berent J
- Abstract
CD4(+)CD25(+)FOXP3(+) Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in human. Experiments in mice demonstrated that Treg restrict effector T cell (Teff) responses by deprivation of the growth factor IL-2 through Treg consumption, resulting in apoptosis of Teff.
- Publication
PloS one, 2009, Vol 4, Issue 9, pe7183
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0007183