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- Title
Whole genome amplification and de novo assembly of single bacterial cells.
- Authors
Rodrigue, Sébastien; Malmstrom, Rex R; Berlin, Aaron M; Birren, Bruce W; Henn, Matthew R; Chisholm, Sallie W
- Abstract
Single-cell genome sequencing has the potential to allow the in-depth exploration of the vast genetic diversity found in uncultured microbes. We used the marine cyanobacterium Prochlorococcus as a model system for addressing important challenges facing high-throughput whole genome amplification (WGA) and complete genome sequencing of individual cells.
- Publication
PloS one, 2009, Vol 4, Issue 9, pe6864
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006864