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- Title
Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo.
- Authors
Ocbina, Polloneal Jymmiel R; Tuson, Miquel; Anderson, Kathryn V
- Abstract
Sonic hedgehog (Shh) signaling in the mouse requires the microtubule-based organelle, the primary cilium. The primary cilium is assembled and maintained through the process of intraflagellar transport (IFT) and the response to Shh is blocked in mouse mutants that lack proteins required for IFT. Although the phenotypes of mouse IFT mutants do not overlap with phenotypes of known Wnt pathway mutants, recent studies report data suggesting that the primary cilium modulates responses to Wnt signals.
- Publication
PloS one, 2009, Vol 4, Issue 8, pe6839
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006839