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- Title
Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.
- Authors
Sequeira, Adolfo; Mamdani, Firoza; Ernst, Carl; Vawter, Marquis P; Bunney, William E; Lebel, Veronique; Rehal, Sonia; Klempan, Tim; Gratton, Alain; Benkelfat, Chawki; Rouleau, Guy A; Mechawar, Naguib; Turecki, Gustavo
- Abstract
Most studies investigating the neurobiology of depression and suicide have focused on the serotonergic system. While it seems clear that serotonergic alterations play a role in the pathogenesis of these major public health problems, dysfunction in additional neurotransmitter systems and other molecular alterations may also be implicated. Microarray expression studies are excellent screening tools to generate hypotheses about additional molecular processes that may be at play. In this study we investigated brain regions that are known to be implicated in the neurobiology of suicide and major depression are likely to represent valid global molecular alterations.
- Publication
PloS one, 2009, Vol 4, Issue 8, pe6585
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006585