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- Title
CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis.
- Authors
Csóka, Balázs; Németh, Zoltán H; Mukhopadhyay, Partha; Spolarics, Zoltán; Rajesh, Mohanraj; Federici, Stephanie; Deitch, Edwin A; Bátkai, Sándor; Pacher, Pál; Haskó, György
- Abstract
Sepsis is a major healthcare problem and current estimates suggest that the incidence of sepsis is approximately 750,000 annually. Sepsis is caused by an inability of the immune system to eliminate invading pathogens. It was recently proposed that endogenous mediators produced during sepsis can contribute to the immune dysfunction that is observed in sepsis. Endocannabinoids that are produced excessively in sepsis are potential factors leading to immune dysfunction, because they suppress immune cell function by binding to G-protein-coupled CB(2) receptors on immune cells. Here we examined the role of CB(2) receptors in regulating the host's response to sepsis.
- Publication
PloS one, 2009, Vol 4, Issue 7, pe6409
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006409