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- Title
Humanin: a novel central regulator of peripheral insulin action.
- Authors
Muzumdar, Radhika H; Huffman, Derek M; Atzmon, Gil; Buettner, Christoph; Cobb, Laura J; Fishman, Sigal; Budagov, Temuri; Cui, Lingguang; Einstein, Francine H; Poduval, Aruna; Hwang, David; Barzilai, Nir; Cohen, Pinchas
- Abstract
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity.
- Publication
PloS one, 2009, Vol 4, Issue 7, pe6334
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006334