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- Title
Polyphasic taxonomic analysis establishes Mycobacterium indicus pranii as a distinct species.
- Authors
Saini, Vikram; Raghuvanshi, Saurabh; Talwar, Gursaran P; Ahmed, Niyaz; Khurana, Jitendra P; Hasnain, Seyed E; Tyagi, Akhilesh K; Tyagi, Anil K
- Abstract
Mycobacterium indicus pranii (MIP), popularly known as Mw, is a cultivable, non-pathogenic organism, which, based on its growth and metabolic properties, is classified in Runyon Group IV along with M. fortuitum, M. smegmatis and M. vaccae. The novelty of this bacterium was accredited to its immunological ability to undergo antigen driven blast transformation of leukocytes and delayed hypersensitivity skin test in leprosy patients, a disease endemic in the Indian sub-continent. Consequently, MIP has been extensively evaluated for its biochemical and immunological properties leading to its usage as an immunomodulator in leprosy and tuberculosis patients. However, owing to advances in sequencing and culture techniques, the citing of new strains with almost 100% similarity in the sequences of marker genes like 16S rRNA, has compromised the identity of MIP as a novel species. Hence, to define its precise taxonomic position, we have carried out polyphasic taxonomic studies on MIP that integrate its phenotypic, chemotaxonomic and molecular phylogenetic attributes.
- Publication
PloS one, 2009, Vol 4, Issue 7, pe6263
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006263