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- Title
Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
- Authors
Banks, Gareth T; Bros-Facer, Virginie; Williams, Hazel P; Chia, Ruth; Achilli, Francesca; Bryson, J Barney; Greensmith, Linda; Fisher, Elizabeth M C
- Abstract
In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal muscular atrophy. GARS is ubiquitously expressed and may have functions in addition to its canonical role in protein synthesis through catalyzing the addition of glycine to cognate tRNAs.
- Publication
PloS one, 2009, Vol 4, Issue 7, pe6218
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006218