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- Title
Influence of smoking on colonic gene expression profile in Crohn's disease.
- Authors
Nielsen, Ole Haagen; Bjerrum, Jacob Tveiten; Csillag, Claudio; Nielsen, Finn Cilius; Olsen, Jørgen
- Abstract
The development and course of Crohn's disease (CD) is related to both genetic and environmental factors. Smoking has been found to exacerbate the course of CD by increasing the risk of developing fistulas and strictures as well as the need for surgery, possibly because of an interaction between smoking or nicotine on macrophage function and the intestinal microvasculature. Several genes are involved in the pathogenesis of CD, and in this study the gene expression differences of the descending colonic mucosa were investigated in CD (smokers or never smokers) and controls (smokers or never smokers).
- Publication
PloS one, 2009, Vol 4, Issue 7, pe6210
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006210