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- Title
Evidence for the concerted evolution between short linear protein motifs and their flanking regions.
- Authors
Chica, Claudia; Diella, Francesca; Gibson, Toby J
- Abstract
Linear motifs are short modules of protein sequences that play a crucial role in mediating and regulating many protein-protein interactions. The function of linear motifs strongly depends on the context, e.g. functional instances mainly occur inside flexible regions that are accessible for interaction. Sometimes linear motifs appear as isolated islands of conservation in multiple sequence alignments. However, they also occur in larger blocks of sequence conservation, suggesting an active role for the neighbouring amino acids.
- Publication
PloS one, 2009, Vol 4, Issue 7, pe6052
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0006052