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- Title
Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
- Authors
Quaye, Lydia; Tyrer, Jonathan; Ramus, Susan J; Song, Honglin; Wozniak, Eva; DiCioccio, Richard A; McGuire, Valerie; Høgdall, Estrid; Høgdall, Claus; Blaakaer, Jan; Goode, Ellen L; Schildkraut, Joellen M; Easton, Douglas F; Krüger-Kjaer, Susanne; Whittemore, Alice S; Gayther, Simon A; Pharoah, Paul D P
- Abstract
Recent studies have identified several single nucleotide polymorphisms (SNPs) in the population that are associated with variations in the risks of many different diseases including cancers such as breast, prostate and colorectal. For ovarian cancer, the known highly penetrant susceptibility genes (BRCA1 and BRCA2) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that other susceptibility genes of lower penetrance exist.
- Publication
PloS one, 2009, Vol 4, Issue 6, pe5983
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005983