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- Title
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.
- Authors
Vitali, Sally H; Mitsialis, S Alex; Liang, Olin D; Liu, Xiaoli; Fernandez-Gonzalez, Angeles; Christou, Helen; Wu, Xinqi; McGowan, Francis X; Kourembanas, Stella
- Abstract
Hypoxia and pressure-overload induce heme oxygenase-1 (HO-1) in cardiomyocytes and vascular smooth muscle cells (VSMCs). HO-1(-/-) mice exposed to chronic hypoxia develop pulmonary arterial hypertension (PAH) with exaggerated right ventricular (RV) injury consisting of dilation, fibrosis, and mural thrombi. Our objective was to identify the HO-1 product(s) mediating RV protection from hypoxic injury in HO-1(-/-) mice.
- Publication
PloS one, 2009, Vol 4, Issue 6, pe5978
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005978