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- Title
Combination therapy using chimeric monoclonal antibodies protects mice from lethal H5N1 infection and prevents formation of escape mutants.
- Authors
Prabakaran, Mookkan; Prabhu, Nayana; He, Fang; Hongliang, Qian; Ho, Hui-Ting; Qiang, Jia; Meng, Tao; Goutama, Michael; Kwang, Jimmy
- Abstract
Given that there is a possibility of a human H5N1 pandemic and the fact that the recent H5N1 viruses are resistant to the anti-viral drugs, newer strategies for effective therapy are warranted. Previous studies show that single mAbs in immune prophylaxis can be protective against H5N1 infection. But a single mAb may not be effective in neutralization of a broad range of different strains of H5N1 and control of potential neutralization escape mutants.
- Publication
PloS one, 2009, Vol 4, Issue 5, pe5672
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005672