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- Title
Prospective identification of malaria parasite genes under balancing selection.
- Authors
Tetteh, Kevin K A; Stewart, Lindsay B; Ochola, Lynette Isabella; Amambua-Ngwa, Alfred; Thomas, Alan W; Marsh, Kevin; Weedall, Gareth D; Conway, David J
- Abstract
Endemic human pathogens are subject to strong immune selection, and interrogation of pathogen genome variation for signatures of balancing selection can identify important target antigens. Several major antigen genes in the malaria parasite Plasmodium falciparum have shown such signatures in polymorphism-versus-divergence indices (comparing with the chimpanzee parasite P. reichenowi), and in allele frequency based indices.
- Publication
PloS one, 2009, Vol 4, Issue 5, pe5568
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005568