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- Title
Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections.
- Authors
Alsharifi, Mohammed; Furuya, Yoichi; Bowden, Timothy R; Lobigs, Mario; Koskinen, Aulikki; Regner, Matthias; Trinidad, Lee; Boyle, David B; Müllbacher, Arno
- Abstract
Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subunit or split flu vaccines rely exclusively on antibody responses for protection and do not induce cytotoxic T (Tc) cell responses, which are broadly cross-reactive between virus strains. We have previously reported that gamma-ray inactivated flu virus can induce cross-reactive Tc cell responses.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5336
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005336