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- Title
Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries.
- Authors
Wyman, Stacia K; Parkin, Rachael K; Mitchell, Patrick S; Fritz, Brian R; O'Briant, Kathy; Godwin, Andrew K; Urban, Nicole; Drescher, Charles W; Knudsen, Beatrice S; Tewari, Muneesh
- Abstract
MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a deadly disease for which improved outcomes could be achieved by successful early detection and enhanced understanding of molecular pathogenesis that leads to improved therapies. A critical step toward these goals is to establish a comprehensive view of miRNAs expressed in epithelial ovarian cancer tissues as well as in normal ovarian surface epithelial cells.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5311
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005311