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- Title
Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data.
- Authors
Corcoran, David L; Pandit, Kusum V; Gordon, Ben; Bhattacharjee, Arindam; Kaminski, Naftali; Benos, Panayiotis V
- Abstract
MicroRNAs (miRNAs) are short, non-coding RNA regulators of protein coding genes. miRNAs play a very important role in diverse biological processes and various diseases. Many algorithms are able to predict miRNA genes and their targets, but their transcription regulation is still under investigation. It is generally believed that intragenic miRNAs (located in introns or exons of protein coding genes) are co-transcribed with their host genes and most intergenic miRNAs transcribed from their own RNA polymerase II (Pol II) promoter. However, the length of the primary transcripts and promoter organization is currently unknown.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5279
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005279