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- Title
Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients.
- Authors
Jacobson, Mark A; Ditmer, Dirk P; Sinclair, Elizabeth; Martin, Jeffrey N; Deeks, Steven G; Hunt, Peter; Mocarski, Edward S; Shiboski, Caroline
- Abstract
Most HIV-infected patients receiving virologically suppressive antiretroviral therapy continue to have abnormal, generalized T cell activation. We explored whether the degree of ongoing cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) replication was associated with higher virus-specific T cell activation and the failure to achieve normal absolute CD4+ T cell counts in the face of long-term suppressive antiretroviral therapy.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5277
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005277