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- Title
In silico whole genome association scan for murine prepulse inhibition.
- Authors
Webb, Bradley Todd; McClay, Joseph L; Vargas-Irwin, Cristina; York, Timothy P; van den Oord, Edwin J C G
- Abstract
The complex trait of prepulse inhibition (PPI) is a sensory gating measure related to schizophrenia and can be measured in mice. Large-scale public repositories of inbred mouse strain genotypes and phenotypes such as PPI can be used to detect Quantitative Trait Loci (QTLs) in silico. However, the method has been criticized for issues including insufficient number of strains, not controlling for false discoveries, the complex haplotype structure of inbred mice, and failing to account for genotypic and phenotypic subgroups.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5246
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005246