We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways.
- Authors
Estep, Preston Wayne, 3rd; Warner, Jason B; Bulyk, Martha L
- Abstract
Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown, and the involvement of the TOR and sirtuin pathways (which regulate aging in simpler organisms) remain controversial. Additionally, females of most mammals appear to live longer than males within species; and, although it remains unclear whether this holds true for mice, the relationship between sex-biased and CR-induced gene expression remains largely unexplored.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5242
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005242