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- Title
Changes in proteasome structure and function caused by HAMLET in tumor cells.
- Authors
Gustafsson, Lotta; Aits, Sonja; Onnerfjord, Patrik; Trulsson, Maria; Storm, Petter; Svanborg, Catharina
- Abstract
Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome response to HAMLET, a partially unfolded protein-lipid complex, which is internalized by tumor cells and triggers cell death.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5229
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005229