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- Title
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.
- Authors
Gingras, Marie-Claude; Zhang, Yu Ling; Kharitidi, Dmitri; Barr, Alastair J; Knapp, Stefan; Tremblay, Michel L; Pause, Arnim
- Abstract
The HD-PTP protein has been described as a tumor suppressor candidate and based on its amino acid sequence, categorized as a classical non-transmembrane protein tyrosine phosphatase (PTP). To date, no HD-PTP phosphorylated substrate has been identified and controversial results concerning its catalytic activity have been recently reported.
- Publication
PloS one, 2009, Vol 4, Issue 4, pe5105
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005105