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- Title
Disease rescue and increased lifespan in a model of cardiomyopathy and muscular dystrophy by combined AAV treatments.
- Authors
Vitiello, Carmen; Faraso, Stefania; Sorrentino, Nicolina Cristina; Di Salvo, Giovanni; Nusco, Edoardo; Nigro, Gerardo; Cutillo, Luisa; Calabrò, Raffaele; Auricchio, Alberto; Nigro, Vincenzo
- Abstract
The BIO14.6 hamster is an excellent animal model for inherited cardiomyopathy, because of its lethal and well-documented course, due to a spontaneous deletion of delta-sarcoglycan gene promoter and first exon. The muscle disease is progressive and average lifespan is 11 months, because heart slowly dilates towards heart failure.
- Publication
PloS one, 2009, Vol 4, Issue 3, pe5051
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0005051