We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein.
- Authors
Cooper, Helen M; Huang, Jing-Yi; Verdin, Eric; Spelbrink, Johannes N
- Abstract
Mammals have seven NAD-dependent protein deacetylases. These proteins, called sirtuins, are homologous to yeast Sir2, and are emerging as important regulators of lifespan and intermediary metabolism. Three mammalian sirtuins, SIRT3-5 are mitochondrial. Sirtuins are highly conserved between species, yet mouse SIRT3 was reported to be markedly shorter than its human counterpart and to lack the N-terminal mitochondrial targeting signal present in the human protein.
- Publication
PloS one, 2009, Vol 4, Issue 3, pe4986
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004986