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- Title
The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family.
- Authors
Fox, Brian A; Sheppard, Paul O; O'Hara, Patrick J
- Abstract
Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone. We have previously described the discovery of the human type-III interferons (IFN lambda-1, -2, -3 or IL-29, IL-28A, IL-28B), which required a combination of manual and computational techniques applied to predicted protein sequences.
- Publication
PloS one, 2009, Vol 4, Issue 3, pe4933
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004933