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- Title
Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder.
- Authors
Rollins, Brandi; Martin, Maureen V; Sequeira, P Adolfo; Moon, Emily A; Morgan, Ling Z; Watson, Stanley J; Schatzberg, Alan; Akil, Huda; Myers, Richard M; Jones, Edward G; Wallace, Douglas C; Bunney, William E; Vawter, Marquis P
- Abstract
Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA (mtDNA) sequence have been reported in SZ and BD patients.
- Publication
PloS one, 2009, Vol 4, Issue 3, pe4913
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004913