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Title
The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
Authors
Hennah, William; Porteous, David
Abstract
Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes.