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- Title
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
- Authors
Willard, Francis S; Willard, Melinda D; Kimple, Adam J; Soundararajan, Meera; Oestreich, Emily A; Li, Xiaoyan; Sowa, Nathaniel A; Kimple, Randall J; Doyle, Declan A; Der, Channing J; Zylka, Mark J; Snider, William D; Siderovski, David P
- Abstract
Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Galpha GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specific effector. However, more recent data from mammals and Drosophila imply that, in vivo, RGS14 may instead be an effector of Ras.
- Publication
PloS one, 2009, Vol 4, Issue 3, pe4884
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004884