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- Title
The coiled coils of cohesin are conserved in animals, but not in yeast.
- Authors
White, Glenn E; Erickson, Harold P
- Abstract
The SMC proteins are involved in DNA repair, chromosome condensation, and sister chromatid cohesion throughout Eukaryota. Long, anti-parallel coiled coils are a prominent feature of SMC proteins, and are thought to serve as spacer rods to provide an elongated structure and to separate domains. We reported recently that the coiled coils of mammalian condensin (SMC2/4) showed moderate sequence divergence (approximately 10-15%) consistent with their functioning as spacer rods. The coiled coils of mammalian cohesins (SMC1/3), however, were very highly constrained, with amino acid sequence divergence typically <0.5%. These coiled coils are among the most highly conserved mammalian proteins, suggesting that they make extensive contacts over their entire surface.
- Publication
PloS one, 2009, Vol 4, Issue 3, pe4674
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004674