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- Title
ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo.
- Authors
Graham, Daniel B; Zinselmeyer, Bernd H; Mascarenhas, Francesca; Delgado, Ryan; Miller, Mark J; Swat, Wojciech
- Abstract
In response to infection, neutrophils are quickly recruited from the blood into inflamed tissues. The interstitial migration of neutrophils is crucial for the efficient capture and control of rapidly proliferating microbes before microbial growth can overwhelm the host's defenses. However, the molecular mechanisms that regulate interstitial migration are incompletely understood.
- Publication
PloS one, 2009, Vol 4, Issue 2, pe4652
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004652