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- Title
Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi.
- Authors
Schmitt, Imke; Lumbsch, H Thorsten
- Abstract
Polyketides are natural products with a wide range of biological functions and pharmaceutical applications. Discovery and utilization of polyketides can be facilitated by understanding the evolutionary processes that gave rise to the biosynthetic machinery and the natural product potential of extant organisms. Gene duplication and subfunctionalization, as well as horizontal gene transfer are proposed mechanisms in the evolution of biosynthetic gene clusters. To explain the amount of homology in some polyketide synthases in unrelated organisms such as bacteria and fungi, interkingdom horizontal gene transfer has been evoked as the most likely evolutionary scenario. However, the origin of the genes and the direction of the transfer remained elusive.
- Publication
PloS one, 2009, Vol 4, Issue 2, pe4437
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004437