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- Title
High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication.
- Authors
Barbour, Jason D; Ndhlovu, Lishomwa C; Xuan Tan, Qi; Ho, Terence; Epling, Lorrie; Bredt, Barry M; Levy, Jay A; Hecht, Frederick M; Sinclair, Elizabeth
- Abstract
The relationship of elevated T cell activation to altered T cell differentiation profiles, each defining features of HIV-1 infection, has not been extensively explored. We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults.
- Publication
PloS one, 2009, Vol 4, Issue 2, pe4408
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004408