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- Title
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer.
- Authors
Björklund, Peyman; Svedlund, Jessica; Olsson, Anna-Karin; Akerström, Göran; Westin, Gunnar
- Abstract
Breast cancer is a common malignant disease, which may be caused by a number of genes deregulated by genomic or epigenomic events. Deregulated WNT/beta-catenin signaling with accumulation of beta-catenin is common in breast tumors, but mutations in WNT signaling pathway components have been rare. An aberrantly spliced internally truncated LRP5 receptor (LRP5Delta666-809, LRP5Delta) was shown recently to be resistant to DKK1 inhibition, and was required for beta-catenin accumulation in hyperparathyroid tumors and parathyroid tumor growth.
- Publication
PloS one, 2009, Vol 4, Issue 1, pe4243
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004243