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- Title
Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans.
- Authors
Serwanga, Jennifer; Shafer, Leigh Anne; Pimego, Edward; Auma, Betty; Watera, Christine; Rowland, Samantha; Yirrell, David; Pala, Pietro; Grosskurth, Heiner; Whitworth, Jimmy; Gotch, Frances; Kaleebu, Pontiano
- Abstract
Some HIV infected individuals remain asymptomatic for protracted periods of time in the absence of antiretroviral therapy (ART). Virological control, CD4 T cell loss and HIV-specific responses are some of the key interrelated determinants of HIV-1 disease progression. In this study, possible interactions between viral load, CD4 T cell slopes, host genetics and HIV-specific IFN-gamma responses were evaluated in chronically HIV-1-infected adults.
- Publication
PloS one, 2009, Vol 4, Issue 1, pe4188
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004188