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- Title
Common and distinct genetic properties of ESCRT-II components in Drosophila.
- Authors
Herz, Hans-Martin; Woodfield, Sarah E; Chen, Zhihong; Bolduc, Clare; Bergmann, Andreas
- Abstract
Genetic studies in yeast have identified class E vps genes that form the ESCRT complexes required for protein sorting at the early endosome. In Drosophila, mutations of the ESCRT-II component vps25 cause endosomal defects leading to accumulation of Notch protein and increased Notch pathway activity. These endosomal and signaling defects are thought to account for several phenotypes. Depending on the developmental context, two different types of overgrowth can be detected. Tissue predominantly mutant for vps25 displays neoplastic tumor characteristics. In contrast, vps25 mutant clones in a wild-type background trigger hyperplastic overgrowth in a non-autonomous manner. In addition, vps25 mutant clones also promote apoptotic resistance in a non-autonomous manner.
- Publication
PloS one, 2009, Vol 4, Issue 1, pe4165
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0004165