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- Title
Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults.
- Authors
Byakika-Tusiime, Jayne; Chinn, Leslie W; Oyugi, Jessica H; Obua, Celestino; Bangsberg, David R; Kroetz, Deanna L
- Abstract
Generic antiretroviral therapy is the mainstay of HIV treatment in resource-limited settings, yet there is little evidence confirming the bioequivalence of generic and brand name formulations. We compared the steady-state pharmacokinetics of lamivudine, stavudine and nevirapine in HIV-infected subjects who were receiving a generic formulation (Triomune) or the corresponding brand formulations (Epivir, Zerit, and Viramune).
- Publication
PloS one, 2008, Vol 3, Issue 12, pe3981
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003981