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- Title
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
- Authors
Managbanag, J R; Witten, Tarynn M; Bonchev, Danail; Fox, Lindsay A; Tsuchiya, Mitsuhiro; Kennedy, Brian K; Kaeberlein, Matt
- Abstract
Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential targets for therapeutic intervention in multiple age-associated diseases, including cancer, heart disease, diabetes, and neurodegenerative disorders. To date, however, targeted efforts at identifying longevity-associated genes have been limited by a lack of predictive power, and useful algorithms for candidate gene-identification have also been lacking.
- Publication
PloS one, 2008, Vol 3, Issue 11, pe3802
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003802