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- Title
MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells.
- Authors
Tzur, Galit; Levy, Asaf; Meiri, Eti; Barad, Omer; Spector, Yael; Bentwich, Zvi; Mizrahi, Lina; Katzenellenbogen, Mark; Ben-Shushan, Etti; Reubinoff, Benjamin E; Galun, Eithan
- Abstract
microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs post-transcriptionally. Human embryonic stem cells (hESC), which exhibit the characteristics of pluripotency and self-renewal, may serve as a model to study the role of miRNAs in early human development. We aimed to determine whether endodermally-differentiated hESC demonstrate a unique miRNA expression pattern, and whether overexpression of endoderm-specific miRNA may affect hESC differentiation.
- Publication
PloS one, 2008, Vol 3, Issue 11, pe3726
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003726