We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pilus operon evolution in Streptococcus pneumoniae is driven by positive selection and recombination.
- Authors
Muzzi, Alessandro; Moschioni, Monica; Covacci, Antonello; Rappuoli, Rino; Donati, Claudio
- Abstract
The evolution of bacterial organelles involved in host-pathogen interactions is subject to intense and competing selective pressures due to the need to maintain function while escaping the host immune response. To characterize the interplay of these forces in an important pathogen, we sequenced the rlrA islet, a chromosomal region encoding for a pilus-like structure involved in adherence to lung epithelial cells in vitro and in colonization in a murine model of infection, in 44 clinical isolates of Streptococcus pneumoniae.
- Publication
PloS one, 2008, Vol 3, Issue 11, pe3660
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003660