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- Title
Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study.
- Authors
Letenneur, Luc; Pérès, Karine; Fleury, Hervé; Garrigue, Isabelle; Barberger-Gateau, Pascale; Helmer, Catherine; Orgogozo, Jean-Marc; Gauthier, Serge; Dartigues, Jean-François
- Abstract
Herpes Simplex Virus (HSV) infection has been proposed as a possible risk factor of Alzheimer's Disease (AD) notably because it is neurotropic, ubiquitous in the general population and able to establish lifelong latency in the host. The fact that HSV was present in elderly subjects with AD suggests that the virus could be a co-factor of the disease. We investigated the risk of developing AD in anti-HSV immunoglobulin G (IgG) positive subjects (indicator of a lifelong infection to HSV) and IgM-positive subjects (indicator of primary infection or reactivation of the virus) in a longitudinal population-based cohort of elderly subjects living in the community.
- Publication
PloS one, 2008, Vol 3, Issue 11, pe3637
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003637