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- Title
Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.
- Authors
Stairs, Douglas B; Nakagawa, Hiroshi; Klein-Szanto, Andres; Mitchell, Shukriyyah D; Silberg, Debra G; Tobias, John W; Lynch, John P; Rustgi, Anil K
- Abstract
Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typically associated with the stratified squamous epithelium chronically exposed to acid and bile salts as a result of gastroesophageal reflux disease (GERD). Despite this well-defined epidemiologic association between acid reflux and Barrett's esophagus, the genetic changes that induce this transdifferentiation process in esophageal keratinocytes have remained undefined.
- Publication
PloS one, 2008, Vol 3, Issue 10, pe3534
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003534