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- Title
A computational model for understanding stem cell, trophectoderm and endoderm lineage determination.
- Authors
Chickarmane, Vijay; Peterson, Carsten
- Abstract
Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. In addition, mutual antagonism between two of these and other master regulators have been shown to regulate lineage determination. In particular, an excess of Cdx2 over Oct4 determines the trophectoderm lineage whereas an excess of Gata-6 over Nanog determines differentiation into the endoderm lineage. Also, under/over-expression studies of the master regulator Oct4 have revealed that some self-renewal/pluripotency as well as differentiation genes are expressed in a biphasic manner with respect to the concentration of Oct4.
- Publication
PloS one, 2008, Vol 3, Issue 10, pe3478
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0003478